Simvastatin treatment increases nitrite levels in obese women: Modulation by T−786C polymorphism of eNOS
نویسندگان
چکیده
منابع مشابه
Atherosclerosis: analysis of the eNOS (T786C) gene polymorphism.
The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has been shown to be a promising t...
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Obesity was associated with high serum vaspin concentrations and increased vaspin mRNA expression in human adipose tissue , insulin resistance, and type II diabetes. However, the mechanisms how vaspin secretion may be linked to deterioration of glucose metabolism and insulin sensitivity are not understood. The aim of this work is to explore the effect of dietary regimen for 6 months on serum va...
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Background: This is a case-control study to determine the relationship between endothelial nitric oxide synthase (eNOS) gene -786T/C polymorphism in women with unexplaiend recurrent abortion in comparison with healty women.Materials and Methods: 95 women with history of at least 2 unexplaiend recurrent abortion in the reproductive age range 20-35 years as patients group and 95 healty women (age...
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We hypothesized that the apolipoprotein mimetic peptide L-4F, which induces arterial anti-oxidative enzymes and is vasoprotective in a rat model of diabetes, would ameliorate insulin resistance and diabetes in obese mice. L-4F (2 mg/kg/d) administered to ob/ob mice for 6 weeks limited weight gain without altering food intake, decreased visceral (P < 0.02) and subcutaneous (P < 0.045) fat conten...
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ژورنال
عنوان ژورنال: Nitric Oxide
سال: 2013
ISSN: 1089-8603
DOI: 10.1016/j.niox.2013.07.005